Gene News and Research

Latest Gene News and Research

$VT3989 shows promising antitumor activity in refractory mesothelioma patients$

VT3989 shows promising antitumor activity in refractory mesothelioma patients

The first-in-class YAP-TEAD inhibitor VT3989 continued to be well tolerated and demonstrated notable initial antitumor activity, particularly in patients with refractory mesothelioma, according to results from a trial led by researchers from The University of Texas MD Anderson Cancer Center.

22 Oct 2025

Oral targeted therapy shrinks tumors in over 70% of patients with HER2-mutant NSCLC

The oral targeted therapy sevabertinib led to tumor reduction and manageable side effects in patients with HER2-mutant non-small cell lung cancer (NSCLC), according to data from a trial led by researchers at The University of Texas MD Anderson Cancer Center.

22 Oct 2025

Gut bacteria found to make serotonin and boost intestinal motility

Researchers have identified Limosilactobacillus mucosae and Ligilactobacillus ruminis as human gut bacteria capable of producing serotonin by decarboxylating 5-hydroxytryptophan (5-HTP). Their activity enhances intestinal motility and enteric nerve density, linking microbial serotonin synthesis to gut function and potential IBS mechanisms.

21 Oct 2025

Epigenetic editing enables safer and more effective T cell therapies

Arc Institute, Gladstone Institutes, and University of California, San Francisco, scientists have developed an epigenetic editing platform that enables safe modification of multiple genes in primary human T cells, addressing a key manufacturing and scalability challenge in next-generation cell therapies.

21 Oct 2025

Researchers develop a novel approach to monitor CD8⁺ T cell activity over time

The ability of immune cells-particularly CD8+ T cells-to launch a rapid burst of proliferation inside tumors is key to the success of modern day cancer immunotherapies.

21 Oct 2025

Genetic inflammatory signature defines depression subtypes and treatment response

Researchers led by Prof. Alessandro Serretti at Kore University of Enna have identified a genetic inflammatory signature that defines specific depression subtypes and influences how patients respond to antidepressant medications, according to new peer-reviewed research published today in Genomic Psychiatry.

21 Oct 2025

New AI-driven approach identifies treatments to reprogram and destroy cancer stem cells

Scientists at University of California San Diego have developed a new approach to destroying cancer stem cells – hard-to-find cells that help cancers spread, come back after treatment and resist therapy.

21 Oct 2025

Women with isolated REM sleep behavior disorder show lesser brain atrophy than men

A large international study involving nearly 700 participants reveals that women with a precursor condition to Parkinson's disease show significantly less brain atrophy—decreased cortical thickness in the brain—than men, despite similar clinical severity.

21 Oct 2025

New study offers hope for patients with treatment-resistant focal epilepsy

About one-third of patients with focal epilepsy, a common form of the neurological disorder, are believed to respond poorly to available therapies.

21 Oct 2025

Molecular evidence connects higher childhood cognitive function to longer lifespan

Researchers led by Dr. W. David Hill at the University of Edinburgh have identified a significant genetic correlation between childhood cognitive function and longevity, providing the first molecular genetic evidence that intelligence measured in youth shares genetic factors with lifespan.

21 Oct 2025

Genetic and inflammatory factors amplify the link between earlier menopause and cognitive risk

Women are significantly more likely than men to develop Alzheimer's disease. Earlier age at menopause is associated with a greater risk for late-life cognitive decline and Alzheimer's disease.

21 Oct 2025

Researchers engineer a tool to dismantle cancer's RNA-built growth hubs

In a city, coworking hubs bring people and ideas together. Inside cancer cells, similar hubs form-but instead of fueling progress, they supercharge disease. That's what researchers at the Texas A&M University Health Science Center (Texas A&M Health) have discovered inside the cells of a rare and aggressive kidney cancer.

21 Oct 2025

MRI age clocks reveal how each organ ages differently and predict who develops disease or lives longer

Researchers developed seven MRI-based biological age clocks across major organs using UK Biobank imaging, linking each to proteins, metabolites, genetics, disease risks, mortality, and cognitive decline. These organ-specific age gaps reveal how uneven aging shapes vulnerability to conditions such as diabetes, hypertension, and dementia, opening new paths for precision prevention and clinical trial stratification

19 Oct 2025

Oral combination regimen improves survival in ER-positive HER-2-negative breast cancer

Patients with estrogen-receptor-positive HER-2-negative advanced breast cancer showed significantly improved progression-free survival when treated with an oral combination regimen that includes giredestrant, a novel, next-generation selective estrogen receptor degrader and full antagonist, compared to a standard combination approach.

18 Oct 2025

Study reveals how a microglial mutation increases risk for Alzheimer's disease

Dominika Pilat, PhD, and Ana Griciuc, PhD, of the Department of Neurology at Massachusetts General Hospital are the lead and senior authors of a paper published in Neuron, "The Gain-of-Function TREM2-T96K Mutation Increases Risk for Alzheimer's Disease by Impairing Microglial Function."

17 Oct 2025

Researchers achieve proof of concept for generating eggs from somatic cells

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Gene News and Research

Latest Gene News and Research

VT3989 shows promising antitumor activity in refractory mesothelioma patients

Oral targeted therapy shrinks tumors in over 70% of patients with HER2-mutant NSCLC

Gut bacteria found to make serotonin and boost intestinal motility

Epigenetic editing enables safer and more effective T cell therapies

Researchers develop a novel approach to monitor CD8⁺ T cell activity over time

Genetic inflammatory signature defines depression subtypes and treatment response

New AI-driven approach identifies treatments to reprogram and destroy cancer stem cells

Women with isolated REM sleep behavior disorder show lesser brain atrophy than men

New study offers hope for patients with treatment-resistant focal epilepsy

Molecular evidence connects higher childhood cognitive function to longer lifespan

Genetic and inflammatory factors amplify the link between earlier menopause and cognitive risk

Researchers engineer a tool to dismantle cancer's RNA-built growth hubs

MRI age clocks reveal how each organ ages differently and predict who develops disease or lives longer

Oral combination regimen improves survival in ER-positive HER-2-negative breast cancer

Study reveals how a microglial mutation increases risk for Alzheimer's disease

Researchers achieve proof of concept for generating eggs from somatic cells

New 3D human brain tissue platform integrates all major brain cell types into a single culture

Scientists discover why a powerful leukemia drug fails in most patients

Runx1 overexpression triggers early intervertebral disc degeneration

Restoring pleiotrophin shows promise for improving brain function in Down syndrome

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

How GLP‑1 Agonists Are Shaping the Future of Obesity Treatment With Dr Bryony Henderson

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production